Friday, February 25, 2011
Thursday, February 24, 2011
My head has been buried in the sand
I've been really good lately about ignoring the the one thing I don't want to talk about. Recently, another blogger mentioned that you can tell when someone is doing poorly on their weight loss plan. It's when they talk about everything except their weight loss plan.
I know that blogger was talking about me (actually, I don't think they even know I exist...but still, that's me). I talk about my cat, about being sick with a cold, my toothache, and recently I've even been chatting about the weather. Really, the weather?
Sorry dear readers. To the few of you that still remain faithful, I haven't exactly been open and honest about my weight loss, or rather, my lack of weight loss.Or in reality, my weight gain. It's very apparent I've been avoiding the obvious. Even if I should happen to even mention trying to lose weight or talk about getting healthy, I quickly gloss over it hoping you don't notice that I really haven't been into it lately.
About that blogger I mentioned above, they were right in their analysis. The weight loss hasn't been going well for me. I have a lot of reasons, or rather excuses. They really aren't even worth mentioning, but here they are: I've been sick, I'm tired all the time, it's cold outside, I've lost desire, I don't care anymore, my work is stressful (some things never change), or, and you've got to love this one because it's my favorite...I just don't feel like it.
It's time
Time for what? It's time that I do something about this very unfortunate situation I've put myself in. I have to lose weight. I have to stop talking about it and do it.
I just counted the days until the Seattle Big Climb. My heart sank when I realized I only have 24 DAYS before I have to climb 69 floors. There are 20 people on my Big Climb team. I am the team captain. One of the people on my team is the president of my company. I've heard he's a very nice person. Although we've met a few times, he doesn't know me, but he knows the person we're honoring with our climb. The president went to high school with one of the guys on my team (on my work team and my Big Climb team). They're good friends.
So it's not like I can say I'm not doing this thing. That's not even within the realm of possibilities. I have to go, put on my cheerleader hat and literally, take one for the team. Or in this case, take 1,311 stair steps for the team. Really though, this isn't about me. It's about raising money for research for leukemia and other blood cancers. Reading this guy's blog reminded me once again of why I'm doing this (it's not for me or about me, it's for a greater good).
About my weight gain
I weighed two days ago at home, no clothes, in the morning before breakfast. I was HORRIFIED to see 183.4 on the scales. I practically ran screaming from the room. How on earth did I let this happen? And now, of all times, with a very difficult, physical challenge facing me on March 20. I don't know. I just know it happened. Excuses are acceptable, and none would help at this point anyway.
Setting a goal with fierce resolve
I have exactly 24 DAYS until B.C. DAY (Big Climb Day = March 20). I can either throw in the towel and say there's nothing I can accomplish in that short amount of time, or I can give it 110% of my effort. I'm choosing the last one. I'm going for it. I know I can at least make a dent in the damage I've done.
My goal is pretty aggressive, but here it is:
Ten pounds in 24 days
Fierce resolve is a desirable quality in an employee. It's referring to intense professional will. It's something that's encourage where I work. Why can't I apply this concept to weight loss? What if I have fierce resolve to lose this weight? An intense will to lose weight. Imagine what I could do with this. I had it at one time, then I quietly and conveniently let it slip away from me.
It's really easier to not have fierce resolve about weight loss. Fierce resolve is hard work, especially for someone like myself, that has struggled with my weight my entire adult entire life.
I was reading about fierce resolve on the internet, and came across an interesting article. I borrowed this paragraph from the article:
Reality can and does bend at our will. This is where the phrase fierce resolve clarifies itself. When you are firmly decided upon a goal, you cultivate the resolution to achieve. You don't do this half-hearted.
My head is out of the sand.
Grilled Peaches on the Half Shell
(makes 4 servings)
Ingredients:
- 4 ripe peaches
- 1 cup fresh or frozen raspberries or blueberries
- 2-3 tbsp brown sugar
- 4 tsp fresh squeezed lemon juice.
Preparation:
- Prepare grill. Wash and halve peaches. Remove pits and discard.
- Place one halved peach, cut side up on a square of aluminum foil. Fill cavity with berries.
- Sprinkle berries with brown sugar then drizzle with lemon juice.
- Bring sides of foil up and wrap over top and sides of the peach. Repeat process with other peach half.
- Grill about 15-20 minutes. Serve warm
Make 4 Servings:
Weight loss recipes Amount Per Serving(¼ of recipe (144 g)): 86 Calories, 1 g Protein, 22 g carbohydrates, 3 g Dietary Fiber, 0 g fat, 0 g saturated fat, 0 mg cholesterol, 5 mg sodiumPolyphenols, Hormesis and Disease: Part II
In the last post, I explained that the body treats polyphenols as potentially harmful foreign chemicals, or "xenobiotics". How can we reconcile this with the growing evidence that at least a subset of polyphenols have health benefits?
Clues from Ionizing Radiation
One of the more curious things that has been reported in the scientific literature is that although high-dose ionizing radiation (such as X-rays) is clearly harmful, leading to cancer, premature aging and other problems, under some conditions low-dose ionizing radiation can actually decrease cancer risk and increase resistance to other stressors (1, 2, 3, 4, 5). It does so by triggering a protective cellular response, increasing cellular defenses out of proportion to the minor threat posed by the radiation itself. The ability of mild stressors to increase stress resistance is called "hormesis." Exercise is a common example. I've written about this phenomenon in the past (6).
The Case of Resveratrol
Resveratrol is perhaps the most widely known polyphenol, available in supplement stores nationwide. It's seen a lot of hype, being hailed as a "calorie restriction mimetic" and the reason for the "French paradox."* But there is quite a large body of evidence suggesting that resveratrol functions in the same manner as low-dose ionizing radiation and other bioactive polyphenols: by acting as a mild toxin that triggers a hormetic response (7). Just as in the case of radiation, high doses of resveratrol are harmful rather than helpful. This has obvious implications for the supplementation of resveratrol and other polyphenols. A recent review article on polyphenols stated that while dietary polyphenols may be protective, "high-dose fortified foods or dietary supplements are of unproven efficacy and possibly harmful" (8).
The Cellular Response to Oxidants
Although it may not be obvious, radiation and polyphenols activate a cellular response that is similar in many ways. Both activate the transcription factor Nrf2, which activates genes that are involved in detoxification of chemicals and antioxidant defense**(9, 10, 11, 12). This is thought to be due to the fact that polyphenols, just like radiation, may temporarily increase the level of oxidative stress inside cells. Here's a quote from the polyphenol review article quoted above (13):
Nrf2 is one of the main pathways by which polyphenols increase stress resistance and antioxidant defenses, including the key cellular antioxidant glutathione (14). Nrf2 activity is correlated with longevity across species (15). Inducing Nrf2 activity via polyphenols or by other means substantially reduces the risk of common lifestyle disorders in animal models, including cardiovascular disease, diabetes and cancer (16, 17, 18), although Nrf2 isn't necessarily the only mechanism. The human evidence is broadly consistent with the studies in animals, although not as well developed.
One of the most interesting effects of hormesis is that exposure to one stressor can increase resistance to other stressors. For example, long-term consumption of high-polyphenol chocolate increases sunburn resistance in humans, implying that it induces a hormetic response in skin (19). Polyphenol-rich foods such as green tea reduce sunburn and skin cancer development in animals (20, 21).
Chris Masterjohn first introduced me to Nrf2 and the idea that polyphenols act through hormesis. Chris studies the effects of green tea on health, which seem to be mediated by polyphenols.
A Second Mechanism
There is a place in the body where polyphenols are concentrated enough to be direct antioxidants: in the digestive tract after consuming polyphenol-rich foods. Digestion is a chemically harsh process that readily oxidizes ingested substances such as polyunsaturated fats (22). Oxidized fat is neither healthy when it's formed in the deep fryer, nor when it's formed in the digestive tract (23, 24). Eating polyphenol-rich foods effectively prevents these fats from being oxidized during digestion (25). One consequence of this appears to be better absorption and assimilation of the exceptionally fragile omega-3 polyunsaturated fatty acids (26).
What does it all Mean?
I think that overall, the evidence suggests that polyphenol-rich foods are healthy in moderation, and eating them on a regular basis is generally a good idea. Certain other plant chemicals, such as suforaphane found in cruciferous vegetables, and allicin found in garlic, exhibit similar effects and may also act by hormesis (27). Some of the best-studied polyphenol-rich foods are tea (particularly green tea), blueberries, extra-virgin olive oil, red wine, citrus fruits, hibiscus tea, soy, dark chocolate, coffee, turmeric and other herbs and spices, and a number of traditional medicinal herbs. A good rule of thumb is to "eat the rainbow", choosing foods with a variety of colors.
Supplementing with polyphenols and other plant chemicals in amounts that would not be achievable by eating food is probably not a good idea.
* The "paradox" whereby the French eat a diet rich in saturated fat, yet have a low heart attack risk compared to other affluent Western nations.
** Genes containing an antioxidant response element (ARE) in the promoter region. ARE is also sometimes called the electrophile response element (EpRE).
Clues from Ionizing Radiation
One of the more curious things that has been reported in the scientific literature is that although high-dose ionizing radiation (such as X-rays) is clearly harmful, leading to cancer, premature aging and other problems, under some conditions low-dose ionizing radiation can actually decrease cancer risk and increase resistance to other stressors (1, 2, 3, 4, 5). It does so by triggering a protective cellular response, increasing cellular defenses out of proportion to the minor threat posed by the radiation itself. The ability of mild stressors to increase stress resistance is called "hormesis." Exercise is a common example. I've written about this phenomenon in the past (6).
The Case of Resveratrol
Resveratrol is perhaps the most widely known polyphenol, available in supplement stores nationwide. It's seen a lot of hype, being hailed as a "calorie restriction mimetic" and the reason for the "French paradox."* But there is quite a large body of evidence suggesting that resveratrol functions in the same manner as low-dose ionizing radiation and other bioactive polyphenols: by acting as a mild toxin that triggers a hormetic response (7). Just as in the case of radiation, high doses of resveratrol are harmful rather than helpful. This has obvious implications for the supplementation of resveratrol and other polyphenols. A recent review article on polyphenols stated that while dietary polyphenols may be protective, "high-dose fortified foods or dietary supplements are of unproven efficacy and possibly harmful" (8).
The Cellular Response to Oxidants
Although it may not be obvious, radiation and polyphenols activate a cellular response that is similar in many ways. Both activate the transcription factor Nrf2, which activates genes that are involved in detoxification of chemicals and antioxidant defense**(9, 10, 11, 12). This is thought to be due to the fact that polyphenols, just like radiation, may temporarily increase the level of oxidative stress inside cells. Here's a quote from the polyphenol review article quoted above (13):
We have found that [polyphenols] are potentially far more than 'just antioxidants', but that they are probably insignificant players as 'conventional' antioxidants. They appear, under most circumstances, to be just the opposite, i.e. prooxidants, that nevertheless appear to contribute strongly to protection from oxidative stress by inducing cellular endogenous enzymic protective mechanisms. They appear to be able to regulate not only antioxidant gene transcription but also numerous aspects of intracellular signaling cascades involved in the regulation of cell growth, inflammation and many other processes.It's worth noting that this is essentially the opposite of what you'll hear on the evening news, that polyphenols are direct antioxidants. The scientific cutting edge has largely discarded that hypothesis, but the mainstream has not yet caught on.
Nrf2 is one of the main pathways by which polyphenols increase stress resistance and antioxidant defenses, including the key cellular antioxidant glutathione (14). Nrf2 activity is correlated with longevity across species (15). Inducing Nrf2 activity via polyphenols or by other means substantially reduces the risk of common lifestyle disorders in animal models, including cardiovascular disease, diabetes and cancer (16, 17, 18), although Nrf2 isn't necessarily the only mechanism. The human evidence is broadly consistent with the studies in animals, although not as well developed.
One of the most interesting effects of hormesis is that exposure to one stressor can increase resistance to other stressors. For example, long-term consumption of high-polyphenol chocolate increases sunburn resistance in humans, implying that it induces a hormetic response in skin (19). Polyphenol-rich foods such as green tea reduce sunburn and skin cancer development in animals (20, 21).
Chris Masterjohn first introduced me to Nrf2 and the idea that polyphenols act through hormesis. Chris studies the effects of green tea on health, which seem to be mediated by polyphenols.
A Second Mechanism
There is a place in the body where polyphenols are concentrated enough to be direct antioxidants: in the digestive tract after consuming polyphenol-rich foods. Digestion is a chemically harsh process that readily oxidizes ingested substances such as polyunsaturated fats (22). Oxidized fat is neither healthy when it's formed in the deep fryer, nor when it's formed in the digestive tract (23, 24). Eating polyphenol-rich foods effectively prevents these fats from being oxidized during digestion (25). One consequence of this appears to be better absorption and assimilation of the exceptionally fragile omega-3 polyunsaturated fatty acids (26).
What does it all Mean?
I think that overall, the evidence suggests that polyphenol-rich foods are healthy in moderation, and eating them on a regular basis is generally a good idea. Certain other plant chemicals, such as suforaphane found in cruciferous vegetables, and allicin found in garlic, exhibit similar effects and may also act by hormesis (27). Some of the best-studied polyphenol-rich foods are tea (particularly green tea), blueberries, extra-virgin olive oil, red wine, citrus fruits, hibiscus tea, soy, dark chocolate, coffee, turmeric and other herbs and spices, and a number of traditional medicinal herbs. A good rule of thumb is to "eat the rainbow", choosing foods with a variety of colors.
Supplementing with polyphenols and other plant chemicals in amounts that would not be achievable by eating food is probably not a good idea.
* The "paradox" whereby the French eat a diet rich in saturated fat, yet have a low heart attack risk compared to other affluent Western nations.
** Genes containing an antioxidant response element (ARE) in the promoter region. ARE is also sometimes called the electrophile response element (EpRE).
The Joy of Gelatin
This year we introduced a new feature in our Cooking with Kaye weekly newsletter titled "All in the Family." The focus is preparing family friendly meals that support our high protein, complex-carbohydrate diet so that we can enjoy meals together eating the same things. We seek to find a way for the entire family to eat delicious, affordable meals that are mindful of our diverse health
Find A Friend in the Neighborhood
Find a Friend in the Neighborhood
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The LivingAfterWLS Neighborhood is your compassion-driven online social space for sharing your weight loss surgery and learning about others with weight loss surgery. We welcome Neighbors with any surgical procedure (or not) and at any stage in their weight management. This is our safe haven circle of friends. Below are quick links to some great
.
The LivingAfterWLS Neighborhood is your compassion-driven online social space for sharing your weight loss surgery and learning about others with weight loss surgery. We welcome Neighbors with any surgical procedure (or not) and at any stage in their weight management. This is our safe haven circle of friends. Below are quick links to some great
Understanding Ketosis in the Weight Loss Surgery High Protein Diet
Often when we hear about a diet that puts the body in a state of ketosis we are fearful having heard that ketosis is a potentially dangerous imbalance of blood glucose, the result of a low carbohydrate, high fat high protein diet. Ketosis results when the body switches from burning glucose for energy to burning ketones for energy. Glucose comes from carbohydrates which are the bodys first choice
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